Download

The Familias software, downloaded below, runs under Windows (Tested on Windows XP and above). Works on other systems with emulated Windows environment.

Download the latest version 3.2.1 (Beta, released 2017-05-08)

Download the latest version 3.2 (Released 2017-03-07)

Download Familias pedigree plotting tool (Released 2017-03-11)

Old versions

Download version: 3.1.9.8 (Released 2016-10-xx)
Download version: 3.1.9.6 (Released 2016-09-19)
Download version: 3.1.9.5 (Released 2016-07-28)
Download version: 3.1.9.4 (Released 2016-04-27)
Download version: 3.1.9.3 (Released 2016-03-01)
Download version: 3.1.9.2 (Released 2015-11-24)
Download version: 3.1.9.1 (Released 2015-11-20)
Download version: 3.1.9 (Released 2015-10-26)

Create pedigree plots (FamiliasPedigreeCreator)

A new tool has been developed that will create pedigree plots for all pedigrees in a specified folder. Below is a link to the software as well as getting started instructions. The software also require the software R to be installed.
FamiliasPedigreeCreator (v 1.1) - Can handle DVI and "normal" Familias projects
FamiliasPedigreeCreator (v 1.0) - Can only handle "normal" Familias projects

Databases

Users will be able to download databases prepared in the Familias (> version 3.0) in this section. Currents users are encouraged to share their Familias frequency database if possible. The allele frequencies are freely available through several online sites as well as usually available from supplementary files in papers on population data.

Validation

The following files can be used to validate new versions of Familas. Results appear in this file. See also the paper Familias 3 - Extensions and new functionality

Installation instructions

The latest version of Familias (version 3.2) will install for most Windows PC:s. For Apple users, and other OS users, a Windows environment can be simulated. In contrast to previous version, the new Familias does not rely on .dll files and can be used as a stand-alone software, i.e. the software can be run from a USB drive. The installation should be straightforward. Should any difficulties be encountered the user are encouraged to contact Daniel Kling. (For installation instructions on the old versions, please see http://familias.name)

English and Spanish instruction videos available here.

There has been several incidents of anti-virus softwares (particulary Symantec products) reporting Familias installation as a threat. This is a false alarm and has been forwarded to Symantec. Users are advised to ignore the message and run the installation anyway. If the error persists or if the installation fails, it may be that administrator rights are needed. The false alarm is caused by the fact that the new Familias is not a widely known software (even though it has quite some users), and as a new line in the defense against new threats the anti-virus softwares has implemented algorithms to search for "new, unknown" softwares/code.


Updates in Familias 3.2.1

  • The XML saving function is now improved allowing to save DVI project and files with Merged profiles.
  • Corrected some minor bugs in the DVI module
  • Improved the merging function. Now when merging profiles profiles will be displayed and the ending profile may be a combination of the two merged ones.
  • Some minor improvements to the plotting function.
  • Further corrections of some incorrectly recognized relationships in the "Import reference family" function of the DVI module.

Updates in Familias 3.2

  • Corrected some bugs detected when switching databases in Familias. Switching could cause a crash or wrong genotypes of individuals.
  • Further improvements when importing large xml databases in the familial searching module.
  • Greatly improved speed and memory handling in the blind search interface.
  • Update to the Direct-matching function in the blind search module. Dropout/Dropin/typing errors are now also considered in the denominator.
  • Information about merged profiles are now stored and can be viewed via Tools->Merged profiles. Reports may be generated as well as undoing a merge if necessary.
  • Corrected a bug that made the force minor allele frequency function not to work. For users not familiar with this feature, it allows you to force the frequencies to sum to more than 1 by using a specific MAF for each marker.
  • Exciting new feature in the DVI module: Evalute each families potential to identify a missing person (Paper in preparation). This feature allows you to perform simulation on all reference families in a DVI project to obtain all kinds of different information. We must admit, a really nice new feature.
  • Some minor bugs corrected in the DVI module.
  • Users may now run a Mendelian inheritance check on any family in the DVI module.
  • Save a project as xml (Beta). This works both as a report when LR computations have been done or use the Save as function to save the whole project. Does not work on DVI or Familial searching projects yet.
  • Greatly enhanced plotting functions, please see complete section in Manual.
  • Lumping of alleles is now allowed within the Advanced dialog. (File -> Advanced). This is currently in early Alpha testing. Briefly it allows the user to specify a threshold. This threshold applies to the probability to mutate (i.e. to observe) an allele not observed in the case data. This way even the mutation matrix for the extended stepwise model can be condensed without any bigger changes to the likelihood. We refer to future version of Familias where this feature will be explained more in detail.

Updates in Familias 3.1.9.6

  • Corrected some minor bugs in the DVI module
  • Improved the plotting function for pedigrees
  • Plot genotypes of persons usingt the R-export function
  • Search only selected persons and families in the DVI module
  • Include IBS parameters in the familial searching module.
  • Corrected some bugs in the import features (both reference families and xml files)

Updates in Familias 3.1.9.5

  • Fixed some bugs in the Familias searching module causing a crash when importing xml files
  • Plotting pedigrees function has been further improved
  • Sorting functions in the DVI module to sort reference families and unidentified persons
  • Bug that appared when building DVI reports has now been fixed
  • NA (Not applicable) will now appear as the LR when scaling against a pedigree with zero likelihood
  • Markers with the same name can no longer be defined
  • Some corrections to the proportional mutation model have been made
  • Fixed some other minor bugs

Updates in Familias 3.1.9.4

  • Quick fix of some minor bugs that appeared in the previous version
  • Plotting pedigrees function has been improved.
  • Fixed some bugs in the plotting function.
  • Advanced settings are now saved to the project file.
  • Added extra column in the DVI results window. Now the number of mismatches (i.e. likelihood=0) is displayed.
  • Some minor cosmetic changes

Updates in Familias 3.1.9.3

  • Several mayor updates to the Familias searching interface. A paper including a validation of this interface has been submitted.
  • New import format in the DVI module now available for reference family data: Familias projects. Import Familias projects containing complete data with pedigrees.
  • Plot pedigrees feature now available. Requires the freeware R to be installed together with the Familias package. Feature available when editing pedigrees.
  • Removed a bug that could cause bad data import when detecting new/unseen alleles.
  • New export functions in the DVI module
  • Several minor bugs smashed.
Contact
Daniel Kling
rmdakl@ous-hf.no


Latest news
- Buy the new Familias book at Elsevier
- Release of Familias 3.2
- Paper on Familias 3 published in FSI Gen.
- Paper on dropouts in kinship applications published in IJLM.
- Paper on the use of the familial searching module in Familias has been published in FSI Gen.
- Hints on the CAP test 2015 available in Help